CLINICAL PROCEEDINGS

CNSA Clinical Proceedings is a series of educational resources intended to raise awareness about unmet needs in neurology. Topics include Alzheimer’s Disease Psychosis, Pseudobulbar Affect and Rett Syndrome.

Upcoming White Paper

Rett Syndrome

CNSA’s third white paper will focus on Rett Syndrome.  

This paper will convey the clinical perspectives and patient journey of those living with Rett Syndrome, a rare disorder affecting primarily women. The white paper will also explore the unmet needs surrounding timely diagnosis and the benefits of novel treatments. 

The expert panel for this paper is: 

  • Jeffrey Neul, MD, PhD – Chair
  • Dick Gunderman, MD
  • Laura Lehman, MD, MPH
  • Alan K. Percy, MD

 

The expert panel will consider the following topics:

  • The growing, yet understudied burden, of Rett Syndrome on patients’ health status, social and intellectual development, and quality of life 
  • Barriers to timely diagnosis and its impact on patients’ health status 
  • Ways to shorten the timeline to a diagnosis 
  • The relationship between Rett Syndrome and other diseases, including common misdiagnoses 
  • The costs to patients, their families, and the health care system of undiagnosed and untreated Rett Syndrome 
  • The benefits of a novel synthetic analog of the amino‐terminal tripeptide of IGF-1 designed in treating the core symptoms of Rett Syndrome by reducing neuroinflammation and supporting synaptic function. 

 

This Clinical Proceedings white paper is supported in part with a grant from Acadia Pharmaceuticals.  

White Papers

Pseudobulbar Affect (PBA)

This paper conveys the perspectives of neurologists as to the challenges involved in clinically managing patients with PBA. PBA is a complicated condition that is characterized by episodes of sudden uncontrollable and inappropriate laughing or crying. The current PBA diagnosis and clinical management landscapes have pressing needs. 

CNSA’s expert panel considered, from a clinical perspective, the patient journey of those experiencing PBA. Clinicians relied on their real-world experience as well as existing research and the perspectives of other stakeholders to develop the publication.

The expert panel for this paper is:

  • Philip B. Gorelick, MD, MPH – Chair
  • Yvonne Curran, MD
  • Muhammad “Umar” Farooq, MD, FAHA, FACP, RPNI
  • Howard S. Kirshner, MD
  • Richard Zweifler, MD

 

This Clinical Proceedings white paper is being supported in part with a grant from Avanir Pharmaceuticals, Inc.

Download the paper

If you want to learn more, watch CNSA’s webinar about pseudobulbar affect here.

Alzheimer's Disease Psychosis

This paper conveys the clinical perspectives as to the challenges in treating patients with Alzheimer’s disease psychosis when no approved therapy is available. The white paper also explores the impact of the unmet needs of Alzheimer’s disease psychosis on patients, clinicians, caregivers and the health care system, as well as societal ramifications. 

The expert panel for this paper is: 

  • Howard S. Kirshner, MD – Chair 
  • Jeffrey L. Cummings, MD, ScD
  • Patrick Griffith, MD
  • Christina Mayville, MD   
  • William Petrie, MD

 

This Clinical Proceedings white paper was supported in part with a grant from Acadia Pharmaceuticals.  

Download the paper

If you want to learn more, watch CNSA’s webinar about Alzheimer’s disease psychosis here.